Evaluation of recombinant monoclonal antibody SVmab1 binding to NaV1.7 target sequences and block of human NaV1.7 currents

The Preclinical Reproducibility & Robustness (PRR) channel provides a venue for researchers to publish both confirmatory and non-confirmatory studies to help improve reproducibility of results, mitigate publication bias towards positive results and to promote open dialogue between scientists.

During last month three important announcements were made:

1. The advisory board of PRR was expanded by several important scientists dedicated to improve  life sciences,

2. Extensive mislabeling was reported in several reports, most likely only showing the tip of the iceberg,

3. The attempt to replicate the results of the stimulus-triggered acquisition of pluripotency (STAP) protocol published in PRR passed peer review earlier this week.

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